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Publications

Selected publications and software papers

This manually curated list highlights research and software connected to genome architecture modeling.

2026 PNASFI-Chromdata-driven modeling

A data-driven chromatin model reveals spatial and dynamic features of genome organization

Oliveira Junior A. B.; Mello M. F.; Oliveira R. J.; Dodero-Rojas E.; Brahmachari S.; Contessoto V. G.; Onuchic J. N.

Proceedings of the National Academy of Sciences

A full-inversion chromatin model for Hi-C-informed genome organization and chromatin dynamics.

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2025 PNASDT40 cell cycleenergy landscapes

Energy landscape analysis of the development of the chromosome structure across the cell cycle

Contessoto V. G.; Oliveira Junior A. B.; Brahmachari S.; Wolynes P. G.; Di Pierro M.; Onuchic J. N.

Proceedings of the National Academy of Sciences

Maximum entropy energy landscapes for chromosome organization across the cell cycle.

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2025 TECSASAIchromatin annotations

Epigenetics is all you need: A transformer to decode chromatin structural compartments from the epigenome

Dodero-Rojas E.; Mendieta A.; Fehlis Y.; Mayala N.; Contessoto V. G.; Onuchic J. N.

PLOS Computational Biology

Transformer-based prediction of chromatin structural annotations from epigenomic data.

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2024 mammothmodeling contributionancient DNA

Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample

Sandoval-Velasco M.; Dudchenko O.; Rodríguez J. A.; Pérez Estrada C.; Dehasque M.; Fontsere C.; Mak S. S. T.; Khan R.; Contessoto V. G.; Oliveira Junior A. B.; et al.

Cell

3D genome modeling contribution for ancient chromosome architecture.

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2023 Nature Communicationsmosquito genomemechanical cues

Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues

Contessoto V. G.; Dudchenko O.; Aiden E. L.; Wolynes P. G.; Onuchic J. N.; Di Pierro M.

Nature Communications

Data-driven physical simulations of the Aedes aegypti genome.

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2021 OpenMiChroMsimulationchromatin dynamics

A Scalable Computational Approach for Simulating Complexes of Multiple Chromosomes

Oliveira Junior A. B.; Contessoto V. G.; Mello M. F.; Onuchic J. N.

Journal of Molecular Biology

GPU-accelerated chromosome simulations built on OpenMM.

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2021 Nucleome Data Bank3D genomedata platform

The Nucleome Data Bank: web-based resources to simulate and analyze the three-dimensional genome

Contessoto V. G.; Cheng R. R.; Hajitaheri A.; Dodero-Rojas E.; Mello M. F.; Aiden E. L.; Wolynes P. G.; Di Pierro M.; Onuchic J. N.

Nucleic Acids Research

A web resource for 3D genome simulation, analysis, visualization, and sharing.

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2021 Science3D genomicscomparative genomics

3D genomics across the tree of life reveals condensin II as a determinant of architecture type

Hoencamp C.; Dudchenko O.; Elbatsh A. M. O.; Brahmachari S.; Raaijmakers J. A.; van Schaik T.; Sedeño Cacciatore A.; Contessoto V. G.; et al.

Science

Comparative 3D genomics across species with physical modeling of architecture type.

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