2026 PNASFI-Chromdata-driven modeling
A data-driven chromatin model reveals spatial and dynamic features of genome organization
Oliveira Junior A. B.; Mello M. F.; Oliveira R. J.; Dodero-Rojas E.; Brahmachari S.; Contessoto V. G.; Onuchic J. N.
Proceedings of the National Academy of Sciences
A full-inversion chromatin model for Hi-C-informed genome organization and chromatin dynamics.
Read publication
2025 PNASDT40 cell cycleenergy landscapes
Energy landscape analysis of the development of the chromosome structure across the cell cycle
Contessoto V. G.; Oliveira Junior A. B.; Brahmachari S.; Wolynes P. G.; Di Pierro M.; Onuchic J. N.
Proceedings of the National Academy of Sciences
Maximum entropy energy landscapes for chromosome organization across the cell cycle.
Read publication
2025 TECSASAIchromatin annotations
Epigenetics is all you need: A transformer to decode chromatin structural compartments from the epigenome
Dodero-Rojas E.; Mendieta A.; Fehlis Y.; Mayala N.; Contessoto V. G.; Onuchic J. N.
PLOS Computational Biology
Transformer-based prediction of chromatin structural annotations from epigenomic data.
Read publication
2024 mammothmodeling contributionancient DNA
Three-dimensional genome architecture persists in a 52,000-year-old woolly mammoth skin sample
Sandoval-Velasco M.; Dudchenko O.; Rodríguez J. A.; Pérez Estrada C.; Dehasque M.; Fontsere C.; Mak S. S. T.; Khan R.; Contessoto V. G.; Oliveira Junior A. B.; et al.
Cell
3D genome modeling contribution for ancient chromosome architecture.
Read publication
2023 Nature Communicationsmosquito genomemechanical cues
Interphase chromosomes of the Aedes aegypti mosquito are liquid crystalline and can sense mechanical cues
Contessoto V. G.; Dudchenko O.; Aiden E. L.; Wolynes P. G.; Onuchic J. N.; Di Pierro M.
Nature Communications
Data-driven physical simulations of the Aedes aegypti genome.
Read publication
2021 OpenMiChroMsimulationchromatin dynamics
A Scalable Computational Approach for Simulating Complexes of Multiple Chromosomes
Oliveira Junior A. B.; Contessoto V. G.; Mello M. F.; Onuchic J. N.
Journal of Molecular Biology
GPU-accelerated chromosome simulations built on OpenMM.
Read publication
2021 Nucleome Data Bank3D genomedata platform
The Nucleome Data Bank: web-based resources to simulate and analyze the three-dimensional genome
Contessoto V. G.; Cheng R. R.; Hajitaheri A.; Dodero-Rojas E.; Mello M. F.; Aiden E. L.; Wolynes P. G.; Di Pierro M.; Onuchic J. N.
Nucleic Acids Research
A web resource for 3D genome simulation, analysis, visualization, and sharing.
Read publication
2021 Science3D genomicscomparative genomics
3D genomics across the tree of life reveals condensin II as a determinant of architecture type
Hoencamp C.; Dudchenko O.; Elbatsh A. M. O.; Brahmachari S.; Raaijmakers J. A.; van Schaik T.; Sedeño Cacciatore A.; Contessoto V. G.; et al.
Science
Comparative 3D genomics across species with physical modeling of architecture type.
Read publication